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A: Wellbutrin XL (bupropion hydrochloride extended-release tablets) is a prescription medicine used to treat adults with a certain type of depression called major depressive disorder and for. Wellbutrin XL®: At first, 150 mg once a day in the morning. 95 Shipping Bupropion Oral tablet, extended release 24 hour drug summary. The XL version is an extended-release formula and is usually taken once daily. Visit cvs. Are Bupropion/Wellbutrin 300 mg XL extended release shells supposed to be empty when they are passed, or are they supposed to be full of a white powdery substance? When used as a treatment for a mood disorder, this medication produces its full effect only after a few weeks. Pharmacies and international online pharmacies accredited through the PharmacyChecker Verification Program. 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