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The cost may outweigh the benefits alli is an FDA approved weight loss supplement that helps block about 25 percent Acts as an effective weight loss product and diet pill for both women and men. 1/10 Before Taking This Medicine You should not use alli if you are allergic to orlistat, or if you have malabsorption syndrome (an inability to absorb food and nutrients properly) What Happens If I Miss A Dose? Here's what you should know about the most common prescription weight loss drugs: liraglutide  (Saxenda), naltrexone-bupropion  (Contrave),  orlistat  (Alli, Xenical), phentermine  (Adipex-P,. The diet pill is not an easy fix for weight loss, but it may help some people lose more weight and improve their health than lifestyle changes alone alli is recommended for those with a BMI over 25. Alli (orlistat 60 mg) is the only FDA approved, over-the-counter weight loss product. 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